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Harp PM, Hahn BH: Origins of HIV and the AIDS Pandemic. Cold Spring Harb Perspect Med 2011, 1:a006841. 3. Brennan CA, Bodelle P, Coffey R, Devare SG, Golden A, Harris B, Holzmayer V, Luk KC, Schochetman G, Swanson P, Yamaguchi J, Vallari A, Ndembi N, Ngansop C, Makamche F, Mbanya D, Gurtler LG, Zekeng L, Kaptue L, Hackett J Jr: The prevalence of diverse HIV-1 strains was stable in Cameroonian bloo
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Tential impact of HIV-1 diversity on both vaccine development and the sustainability of antiretroviral therapies, it is particularly important that molecular epidemiological surveillance is continued in HIV diversity hotspots such as Cameroon. In this study we have focused on characterizing the diversity of gag and nef genes of Cameroonian HIV-1 isolates. These genes are?2013 Tongo et al.; license
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Cer patients showing CISH EGFR GCN 2.12 (-------) and CISH EGFR GCN
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F known clades. Although the majority of the outlier viruses found in our study were also URFs, they remained outliers after the removal of recombinant segments. It thus appears that these sequences represent viruses that are genuinely highly divergent and are possibly extant descendants of previously unknown early divergingTable 3 Inter and intraclade recombinantsSample ID BS02 BS09 BS11 BS13 BS2
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Es represent the gag sequences sampled from Cameroon in this study, while red squares represent intragene recombinant fragments in our samples. The blue squares show the new divergent branches formed by viruses sampled in this study. Sequence C.ZM.2006.ZM1464F appears to have been mis-labelled in the LANL database, and consistently groups with subtype A1. Additional file 2: Detailed phylogenetic a
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F known clades. Although the majority of the outlier viruses found in our study were also URFs, they remained outliers after the removal of recombinant segments. It thus appears that these sequences represent viruses that are genuinely highly divergent and are possibly extant descendants of previously unknown early divergingTable 3 Inter and intraclade recombinantsSample ID BS02 BS09 BS11 BS13 BS2
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Hose residing on isolated branches outside of subtrees containing previously defined HIV-1 subtype or CRF lineages. Outlier sequences on the other hand were defined as those residing on basal branches of subtrees containing previously defined HIV-1 subtype or CRF lineages. Nucleotide sequences were deposited in GenBank [JX244899-JX244948 for gag and JX244949JX245003 for nef]. Clinical and demograp
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Mpled sequences are likely CRF02_AG (accounting for 50 of HIV-1M infections), with the other "pure" subtypes (G, D, A, and F) and CRFs (CRF11_cpx, 36_cpx, 37_cpx, and CRF01_AE) accounting for the remainder of infections. CRF02_AG and clade G viruses are broadly distributed across west central Africa and have apparently been circulating stably there for many years [3,17-19], consistent with the pr

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